Tuesday, July 31, 2012

Microsoft trumpets Windows Phone 7 numbers on first birthday

Happy first birthday, Windows Phone 7! One year on, and the fledgling mobile operating system has 36,000 active developers in its AppHub community, 1.5 million downloads of its Developer Tools, and 11,500 apps in its Marketplace.

Microsoft is quick to take a couple shots at competitors? app stores, beating its chest about not re-counting tanslations of an app or ?lite? apps, ?increasing tonnage? by supporting apps from other mobile platforms, and not listing wallpapers as a category.

That?s all fine and dandy, but we spend a lot of time sifting through WP7 app feeds ? and we?re still not seeing a lot of awesome apps on the platform. We think a few marquee apps would?ve made a pretty nice first birthday present ? along with a much smoother update process for WP7 users.

Microsoft trumpets Windows Phone 7 numbers on first birthday originally appeared on Download Squad on Fri, 01 Apr 2011 11:00:00 EST. Please see our terms for use of feeds.

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Source: http://downloadsquad.switched.com/2011/04/01/microsoft-trumpets-windows-phone-7-numbers-on-first-birthday/

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Source: http://www.aclararpiel.org/blog/2012/07/29/microsoft-trumpets-windows-phone-7-numbers-on-first-birthday-3/

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Judge clears Arizona's late-term abortion ban to take effect

PHOENIX (Reuters) - A federal judge refused on Monday to block an Arizona law banning most abortions after 20 weeks of pregnancy, clearing the way for the statute to take effect this week.

District Judge James Teilborg ruled that the measure, passed by the Republican-controlled state legislature and signed into law in April by Republican Governor Jan Brewer, is in keeping with standards that federal courts have set on limits to late-term abortions.

The new statute, due to take effect on Thursday, bars healthcare professionals from performing abortions after 20 weeks of pregnancy, except in the case of a medical emergency. Only a small number of such abortions are performed in the state each year.

Siding against abortion-rights advocates who had challenged the law, Teilborg said Arizona's ban "does not impose a substantial obstacle" to abortions generally and that Arizona has the right to pass such legislation.

Two groups, the Center for Reproductive Rights and the American Civil Liberties Union, filed suit earlier this month on behalf of three Arizona abortion providers seeking to prevent the ban from being implemented.

The suit was believed to mark the first court test brought by physicians against similar abortion restrictions that have surfaced in a growing number of states since Republicans gained greater statehouse clout in the November 2010 elections, Center for Reproductive Rights officials said.

Six states have put laws into effect in the past two years banning most or all late-term abortions, based on hotly debated medical research suggesting that a fetus feels pain starting at 20 weeks of gestation. North Carolina enacted its own such ban decades ago.

Arizona and two other states - Georgia and Louisiana - have enacted similar bans that have not yet taken effect, center officials said.

The Supreme Court legalized abortion in 1973 but allowed states to place restrictions on the procedure from the time when a fetus could potentially survive outside the womb, except when a woman's health was at risk.

(Editing by Steve Gorman and Will Dunham)

Source: http://news.yahoo.com/judge-clears-arizonas-term-abortion-ban-effect-210650296.html

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Saturday, July 28, 2012

HBT: Harvey the next Strasburg, Verlander?

Matt Harvey?s debut was fantastic. It easily stands as the most excitement Mets fans have had for a while, and stands as great hope for the future.

But jeez, Terry Collins: maybe you need to ease up on the pressure a bit?

?I?ve talked to scouts who think he is a three or a four [starter], let me tell you something, that?s No. 1 kind of stuff right there, that?s [Justin] Verlander, [Stephen] Strasburg stuff,?? he said.

It may very well be awesome stuff. But man, even guys with the best stuff don?t become that good very often. And in a place like New York, people will remember that stuff and, if Harvey somehow doesn?t become a regular Cy Young candidate, folks are gonna think of him,?unfairly, as a flop.

Source: http://hardballtalk.nbcsports.com/2012/07/27/no-pressure-terry-collins-compares-matt-harvey-to-strasburg-verlander/related/

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France's Socialists take aim with new budget

PARIS (AP) ? President Francois Hollande's new Socialist administration is starting to shake up French policy on whom to tax and how to spend ?changes that would effectively roll back much of what ex-President Nicholas Sarkozy and his center-right government accomplished.

Under an amended 2012 budget being pushed through Parliament, wealthy people and large companies are likely to see more of their earnings taxed, while government spending has remained largely untouched. The budget is a clear contrast with the rest of Europe, where austerity cuts are being introduced to reduce deficits. The budget also contains provisions that would sweep away efforts by the previous administration to shake up labor market rules that favor workers over businesses.

Business leaders are worried that the first major act as France's new leader will set the tone for the rest of his time in office.

Among the measures in the revised budget, which the lower house passed on Friday and the upper house is currently debating, are:

? scrapping of tax breaks on overtime

? a one-time extra wealth tax on people with more than ?800,000 in assets

? scrapping of a law that would have raised the sales tax while decreasing employer contributions to the state benefit system

? a new tax on company dividends

? a new tax on stocks of petroleum products

? new taxes on some financial institutions and an increase in the financial transaction tax

Debate over the budget in the parliament last week was fierce as members of previous President Nicolas Sarkozy's conservative party fought in vain against a roll-back of much of what they had accomplished over the past five years. At one point, the session was even suspended so the deputies could cool down. The Senate is scheduled to vote on the budget on Friday; both houses are expected to approve a final version next week.

The new government claims the budget measures show that it is serious about reducing the country's deficit. It has already pledged to balance the country's budget by 2017. However, it did not back up the tax hikes with any significant cuts in government spending.

Companies say that the new taxes send out the wrong message: that France is closed for business.

A major part of the France's problem is that its $2.4 trillion economy is stagnant ? the government expects just a 0.3 percent increase in gross domestic product this year. Growth is expected to pick up a bit next year ? the government has predicted 1.2 percent growth, though others say that's optimistic. As growth has slowed, France's debt-to-GDP ratio has exploded, rising 30 percent since the crisis began to 89.2 percent this year.

So far, Hollande's push to cut the deficit appears to have been received well. Earlier this month, the country borrowed ?6 billion in short-term debt at negative interest rates for the first time. Last week, a long-term debt auction also saw borrowing costs fall.

But analysts and business leaders say that chipping away at France's deficit by raising taxes is not a long-term plan. Creating incentives for businesses is going to have to be part of any strategy to restart growth. And new or higher taxes could have the opposite effect.

Guillaume de Fondaumiere, the co-CEO of video game company Quantic Dream which has 170 employees, said he and his fellow businessmen were growing weary of being France's boogeymen.

"We're not expecting medals but a minimum of consideration and help that would allow us to give our best," said de Fondaumiere.

One official from a CAC-40-listed company said the budget sent a message that the government doesn't like business and it doesn't like rich people. He would only speak candidly about the budget on condition of anonymity.

The French government hasn't been shy about saying that the budget bill is targeting the rich. This is an administration led by Hollande, who once famously said he did not like the rich.

Finance Minister Pierre Moscovici defended it in parliament as a law that "again puts justice at the heart of our tax system."

Justice is the watchword of Hollande's new team. His administration says it's committed to balancing the budget but that how they do it ? by making the rich pay more and maintaining programs for the poor ? will be just as important as that they're doing it.

Some had hoped Hollande would play on the Socialists' history of close connections with the country's powerful unions to reform a stagnant labor market ? where both hiring and firing are expensive. Instead, the new budget paints a picture of an administration more concerned with protecting benefits like early retirement and generous unemployment insurance ? measures that have defined French Socialism for decades.

"It's classic leftism," said Jean-Thomas Lesueur, a political analyst at the Institut Thomas More, a pro-market think tank based in Paris and Brussels.

There's one measure in particular ? the repeal in a law that cuts the amount employers pay into the social security system ? that has raised employers' hackles. The cost of hiring ? and firing ? in France is often blamed for the country's perennially high unemployment. In the past 20 years, the annual unemployment figure has never been less than 7.4 percent, according to national statistics. It has been over 10 percent, where it stands now, for most of the 1990s.

What was missing from the budget measures was any sign of real spending cuts. Such measures will have to wait until Hollande's administration writes the budget for 2013 this fall.

"This is a strong message to everyone ... that the government has not understood the urgency of reducing public expenditure," said Lesueur.

France has been spending more than it takes in revenue for a long time and the crisis over too much debt among the other members of the 17-country eurozone threatens to bring the problem to a head.

The country's borrowing rates have occasionally spiked sharply since last summer on fears that the country is not cutting its spending or reforming its labor market to encourage more growth.

"When the storm comes, I'm not sure if we'll have the means to react," Lesueur said.

While the government has yet to divulge its full strategy to right France's finances, it has promised to "reindustrialize" France ? part of a grand plan to restart growth and keep manufacturing jobs in the country. Hollande has even created a Ministry for Industrial Recovery. Its first act will be to set about renegotiating a cost-cutting plan that would eliminate 8,000 jobs at carmaker Peugeot Citroen.

Companies across France are closely watching those talks as they wonder if they might next be in the government's sights ? but also what kinds of incentives the government is offering to keep or create jobs. A grand plan to remake France as a center green vehicle production was unveiled on Wednesday as part of an effort to save the country's auto industry.

This highlights France's split personality: On the one hand, many companies will complain about a government threat to prevent profitable enterprises from laying off workers; on the other hand, they look to the state to prop them up in tough times.

"It's working less and less well," said Lesueur. "However, since we have made the French so accustomed to public spending, they're drugged."

___

Follow Sarah DiLorenzo at http://twitter.com/sdilorenzo .

Source: http://news.yahoo.com/frances-socialists-aim-budget-092041199.html

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Friday, July 27, 2012

US Q2 GDP - Business Insider

Bill Pugliano/Getty Images

UPDATE:

The U.S. economy expanded by 1.5 percent during the second quarter, topping expecations for a 1.4 percent gain, new data out of the Bureau of Economic Analysis shows.

Nonetheless, the government figures continued show that the nation's economy is on uneven footing and losing momentum.

During the first three months of the year, the country's gross domestic product expanded by a revised 2.0 percent, moderately faster than the pace seen today.?

Economists have been highlighting the somewhat stalled pace of growth over the past several months as a series of data points have been lackluster.

"Over the past year the US economy, as weak as it has been, has outperformed its peers," Eric Green of TD Securities said ahead of the report. "Coupled with pervasive risk aversion stemming from Europe, and a Fed that has chosen maturity management over balance sheet expansion, it has led to a 13.5% gain in the USD (DXY) since the last annual revisions to GDP."

Aiding growth was a jump in personal consumption of non durable goods and exports.?

Exports advanced 5.3 percent in the second quarter, accelerating from the 4.4 percent gain at the start of 2012.

Non durable goods and services jumped 1.5 percent and 1.9 percent, respectively. Sales of durable goods declined 1.0 percent during the period.

Government spending continued to decline, with total expenditures off 0.4 percent. That's a deceleration from the 4.2 percent fall recorded in the first quarter.?

Personal consumption improved 1.5 percent during the period, a 90 basis point drop from three months earlier.

In current-dollar terms, the BEA said the nation's economy expanded 3.1 percent, or $117.6 billion, to $15.595 trillion.?

?

Below, the full release.

---------------------------

Real gross domestic product -- the output of goods and services produced by labor and property
located in the United States -- increased at an annual rate of 1.5 percent in the second quarter of 2012,
(that is, from the first quarter to the second quarter), according to the "advance" estimate released by the
Bureau of Economic Analysis. In the first quarter, real GDP increased 2.0 percent.

The Bureau emphasized that the second-quarter advance estimate released today is based on
source data that are incomplete or subject to further revision by the source agency (see the box on page
3). The "second" estimate for the second quarter, based on more complete data, will be released on
August 29, 2012.

BOX._____
The estimates released today reflect the regular annual revision of the national income and product
accounts (NIPAs), beginning with the estimates for the first quarter of 2009. Annual revisions, which
are usually released in July, incorporate source data that are more complete, more detailed, and
otherwise more reliable than those previously available. This release includes the revised quarterly
estimates of GDP, corporate profits, and personal income and provides an overview of the effects of the
revision.

The August 2012 Survey of Current Business will contain NIPA tables and an article describing
the revisions. These NIPA tables will be available on BEA?s Web site at www.bea.gov by August 3,
2012.
_________


FOOTNOTE.______
Quarterly estimates are expressed at seasonally adjusted annual rates, unless otherwise
specified. Quarter-to-quarter dollar changes are differences between these published estimates. Percent
changes are calculated from unrounded data and are annualized. "Real" estimates are in chained (2005)
dollars. Price indexes are chain-type measures.

This news release is available on BEA?s Web site along with the Technical Note and Highlights
related to this release.
________________

The increase in real GDP in the second quarter primarily reflected positive contributions from
personal consumption expenditures (PCE), exports, nonresidential fixed investment, private inventory
investment, and residential fixed investment that were partly offset by a negative contribution from state
and local government spending. Imports, which are a subtraction in the calculation of GDP, increased.

The deceleration in real GDP in the second quarter primarily reflected a deceleration in PCE, an
acceleration in imports, and decelerations in residential fixed investment and in nonresidential fixed
investment that were partly offset by an upturn in private inventory investment, a smaller decrease in
federal government spending, and an acceleration in exports.

Motor vehicle output added 0.13 percentage point to the second-quarter change in real GDP after
adding 0.72 percentage point to the first-quarter change. Final sales of computers subtracted 0.07
percentage point from the second-quarter change in real GDP after adding 0.02 percentage point to the
first-quarter change.

The price index for gross domestic purchases, which measures prices paid by U.S. residents,
increased 0.7 percent in the second quarter, compared with an increase of 2.5 percent in the first.
Excluding food and energy prices, the price index for gross domestic purchases increased 1.4 percent in
the second quarter, compared with an increase of 2.4 percent in the first.

Real personal consumption expenditures increased 1.5 percent in the second quarter, compared
with an increase of 2.4 percent in the first. Durable goods decreased 1.0 percent, in contrast to an
increase of 11.5 percent. Nondurable goods increased 1.5 percent, compared with an increase of 1.6
percent. Services increased 1.9 percent, compared with an increase of 1.3.

Real nonresidential fixed investment increased 5.3 percent in the second quarter, compared with
an increase of 7.5 percent in the first. Nonresidential structures increased 0.9 percent, compared with an
increase of 12.9 percent. Equipment and software increased 7.2 percent, compared with an increase of
5.4 percent. Real residential fixed investment increased 9.7 percent, compared with an increase of 20.5
percent.

Real exports of goods and services increased 5.3 percent in the second quarter, compared with an
increase of 4.4 percent in the first. Real imports of goods and services increased 6.0 percent, compared
with an increase of 3.1 percent.

Real federal government consumption expenditures and gross investment decreased 0.4 percent
in the second quarter, compared with a decrease of 4.2 percent in the first. National defense decreased
0.4 percent, compared with a decrease of 7.1 percent. Nondefense decreased 0.3 percent, in contrast to
an increase of 1.8 percent. Real state and local government consumption expenditures and gross
investment decreased 2.1 percent, compared with a decrease of 2.2.

The change in real private inventories added 0.32 percentage point to the second-quarter change
in real GDP after subtracting 0.39 percentage point from the first-quarter change. Private businesses
increased inventories $66.3 billion in the second quarter, following increases of $56.9 billion in the first
quarter and $70.5 billion in the fourth.

Real final sales of domestic product -- GDP less change in private inventories -- increased 1.2
percent in the second quarter, compared with an increase of 2.4 percent in the first.


Gross domestic purchases

Real gross domestic purchases -- purchases by U.S. residents of goods and services wherever
produced -- increased 1.8 percent in the second quarter, the same increase as in the first quarter.


Disposition of personal income

Current-dollar personal income increased $140.5 billion (4.3 percent) in the second quarter,
compared with an increase of $199.9 billion (6.3 percent) in the first.

Personal current taxes increased $24.9 billion in the second quarter, compared with an increase
of $30.0 billion in the first.

Disposable personal income increased $115.6 billion (4.0 percent) in the second quarter,
compared with an increase of $169.9 billion (6.0 percent) in the first. Real disposable personal income
increased 3.2 percent, compared with an increase of 3.4 percent.

Personal outlays increased $59.9 billion (2.1 percent) in the second quarter, compared with an
increase of $143.1 billion (5.2 percent) in the first. Personal saving -- disposable personal income less
personal outlays -- was $475.3 billion in the second quarter, compared with $419.5 billion in the first.
The personal saving rate -- saving as a percentage of disposable personal income -- was 4.0 percent in
the second quarter, compared with 3.6 percent in the first. For a comparison of personal saving in
BEA?s national income and product accounts with personal saving in the Federal Reserve Board?s flow
of funds accounts and data on changes in net worth, go to www.bea.gov/national/nipaweb/Nipa-Frb.asp.


Current-dollar GDP

Current-dollar GDP -- the market value of the nation's output of goods and services -- increased
3.1 percent, or $117.6 billion, in the second quarter to a level of $15,595.9 billion. In the first quarter,
current-dollar GDP increased 4.2 percent, or $157.3 billion.


BOX._________
Information on the assumptions used for unavailable source data is provided in a technical note
that is posted with the news release on BEA's Web site. Within a few days after the release, a detailed
"Key Source Data and Assumptions" file is posted on the Web site. In the middle of each month, an
analysis of the current quarterly estimate of GDP and related series is made available on the Web site;
click on Survey of Current Business, "GDP and the Economy."
_____________

?

Revision of the National Income and Product Accounts


The revised estimates, which begin with 2009, reflect the results of the annual revision of the
national income and product accounts (NIPAs). These revisions, usually made each July, incorporate
newly available and more comprehensive source data, as well as improved estimation methodologies. In
this annual revision, the notable revisions primarily reflect the incorporation of newly available and
revised source data. For example, the revised estimates of profits reflect newly available Internal
Revenue Service tabulations of tax returns for corporations for 2010 and revised tabulations for 2009.

Because of the additional data shown, tables 3, 11, and 12 are each divided into two separate
tables -- 3A and 3B, 11A and 11B, and 12A and 12B. There are also a number of special tables that
compare the revised and previously published estimates for selected periods: table 1A shows the
percent change in real GDP and related measures; table 1B shows revisions to current-dollar GDP, to
national income, and to the disposition of personal income; table 2A shows contributions to the percent
change in real GDP; table 4A shows the percent change in the chain-type price indexes for GDP and
related measures; and table 12C shows revisions to corporate profits by industry.

With the release of the annual revision, statistics for selected NIPA tables will be available on
BEA?s Web site (www.bea.gov). Shortly after the GDP release, BEA will post a table on its Web site
showing the sources of major current-dollar revisions to the annual estimates for 2009?2011 for each
component of GDP, national income, and personal income. The August 2012 Survey of Current
Business will contain NIPA tables and an article describing the revisions. The August 2012 issue will
also contain an analysis of the "advance" GDP estimate for the second quarter of 2012 ("GDP and the
Economy").

This section of the release discusses the highlights of annual revision, including the newly
incorporated source data and changes in methodology and presentation.


Summary of revisions

For this annual revision, the revisions are limited to the period from 2009 to the first quarter of
2012.

* For 2008?2011, real GDP increased at an average annual rate of 0.3 percent; in the previously
published estimates, real GDP had increased at an average annual rate of 0.4 percent. From the
fourth quarter of 2008 to the first quarter of 2012, real GDP increased at an average annual rate
of 1.5 percent; in the previously published estimates, real GDP had increased 1.4 percent.

* The percent change in real GDP was revised up 0.4 percentage point for 2009, was revised down
0.6 percentage point for 2010, and was revised up 0.1 percentage point for 2011.

* The revisions to the annual estimates for 2009?2011 reflect partly offsetting revisions to the
quarters within the year. For example, for 2009, the annual rate of change in GDP was revised
up 1.4 percentage points for the first quarter, was revised up 0.4 percentage point for the second
quarter, and was revised up 0.2 percentage point for the fourth quarter, while the growth rate for
the third quarter was revised down 0.3 percentage point. For 2010, the annual rate of change in
GDP was revised down 1.6 percentage points for both the first and second quarters, while the
growth rates for the third and fourth quarters were each revised up 0.1 percentage point. For
2011, the annual rate of change in GDP was revised up 1.2 percentage points for the second
quarter and was revised up 1.1 percentage points for the fourth quarter, while the growth rates for
the first and third quarters were revised down 0.3 percentage point and 0.5 percentage point,
respectively.

* For the 13 quarters from the first quarter of 2009 to the first quarter of 2012, the average revision
(without regard to sign) was 0.7 percentage point. The revisions did not change the direction of
change in real GDP (increase or decrease) for any quarter.

* For 2008?2011, the average annual rate of growth of real disposable personal income was
revised down 0.1 percentage point, from 0.2 percent to 0.1 percent.

* From the fourth quarter of 2008 to the first quarter of 2012, the average annual rate of increase in
the price index for gross domestic purchases was 1.6 percent, the same rate of increase as in the
previously published estimates. The average annual rate of increase in the price index for
personal consumption expenditures (PCE) was 1.8 percent; in the previously published
estimates, the price index for PCE had increased 1.9 percent. The average annual rate of
increase in the "core" PCE price index (which excludes food and energy) was 1.5 percent; in the
previously published estimates, the "core" PCE price index had increased 1.6 percent.

* The percent change in real gross domestic income (GDI) was revised up 0.1 percentage point for
2009, was revised down 0.5 percentage point for 2010, and was revised down 0.2 percentage
point for 2011.

* National income was revised down for all 3 years: 0.1 percent for 2009, 0.2 percent for 2010,
and 0.5 percent for 2011.

* Corporate profits was revised down for all 3 years: 1.4 percent for 2009, 5.4 percent for 2010,
and 6.0 percent for 2011.


Revisions to the 2009-2011 estimates

The percent change from the preceding year in real GDP was revised up from a decrease of 3.5
percent to a decrease of 3.1 percent for 2009, was revised down from an increase of 3.0 percent to an
increase of 2.4 percent for 2010, and was revised up from an increase of 1.7 percent to an increase of 1.8
percent for 2011.

For 2009, the largest contributors to the revision to the change in real GDP were upward
revisions to state and local government spending and to inventory investment. For 2010, the largest
contributors to the revision were downward revisions to nonresidential fixed investment, to PCE, and to
inventory investment. For 2011, the largest contributors to the revision were upward revisions to PCE
and to inventory investment; these revisions were partly offset by downward revisions to state and local
government spending, to federal government spending, and to nonresidential fixed investment.

The percent change from fourth quarter to fourth quarter in real GDP was revised up from a
decrease of 0.5 percent to a decrease of 0.1 percent during 2009, was revised down from an increase of
3.1 percent to an increase of 2.4 percent during 2010, and was revised up from an increase of 1.6 percent
to an increase of 2.0 percent during 2011.

For the period of contraction from the fourth quarter of 2007 to the second quarter of 2009, real
GDP decreased at an average annual rate of 3.2 percent; in the previously published estimates, it had
decreased 3.5 percent. The cumulative decrease in real GDP (not at an annual rate) was 4.7 percent; in
the previously published estimates, the cumulative decrease was 5.1 percent.

For the period of expansion from the second quarter of 2009 to the first quarter of 2012, real
GDP increased at an average annual rate of 2.3 percent; in the previously published estimates, it had
increased 2.4 percent.

The percent change from the preceding year in real gross domestic income (GDI) was revised up
from a decrease of 4.0 percent to a decrease of 3.9 percent for 2009, was revised down from an increase
of 3.6 percent to an increase of 3.1 percent for 2010, and was revised down from an increase of 2.0
percent to an increase of 1.8 percent for 2011.

The percent change from the preceding year in the price index for gross domestic purchases was
revised down from a decrease of 0.1 percent to a decrease of 0.2 percent for 2009, was revised up from
an increase of 1.5 percent to an increase of 1.6 percent for 2010, and was unrevised at 2.5 percent for
2011. For the corresponding quarters, the largest downward revision was 0.6 percentage point for the
first quarter of 2011; the largest upward revision was 0.4 percentage point (for both the third and fourth
quarters of 2010).

Current-dollar GDP was revised up $34.7 billion, or 0.2 percent, for 2009; was revised down
$27.6 billion, or 0.2 percent, for 2010; and was revised down $18.3 billion, or 0.1 percent, for 2011.
The percent change from the preceding year was revised up from a decrease of 2.5 percent to a decrease
of 2.2 percent for 2009, was revised down from an increase of 4.2 percent to an increase of 3.8 percent
for 2010, and was revised up from an increase of 3.9 percent to an increase of 4.0 percent for 2011.
Current-dollar gross national product (GNP) (GDP plus net receipts of income from the rest of the
world) was revised up $26.0 billion, or 0.2 percent, for 2009; was revised down $7.7 billion, or 0.1
percent, for 2010; and was revised down $12.0 billion, or 0.1 percent, for 2011. Net receipts of income
from the rest of the world was revised down $8.8 billion for 2009, was revised up $19.9 billion for 2010,
and was revised up $6.4 billion for 2011. The revisions to net receipts of income -- which affect GNP,
national income, corporate profits, net interest and miscellaneous payments, and personal income
receipts on assets -- resulted from the revisions to BEA's international transactions accounts (ITAs) that
were released in June. (An article describing the revisions to the ITAs was published in the July 2012
issue of the Survey of Current Business.)

National income was revised down for all 3 years: $15.0 billion, or 0.1 percent, for 2009; $28.7
billion, or 0.2 percent, for 2010; and $62.3 billion, or 0.5 percent, for 2011. For 2009, downward
revisions to corporate profits, to net interest, and to rental income of persons were partly offset by an
upward revision to nonfarm proprietors? income. For 2010, a downward revision to corporate profits
was partly offset by an upward revision to nonfarm proprietors? income. For 2011, a downward revision
to corporate profits was partly offset by upward revisions to nonfarm proprietors? income and to
supplements to wages and salaries.

Corporate profits from current production -- profits before tax with inventory valuation and
capital consumption adjustments -- was revised down for all 3 years: $19.7 billion, or 1.4 percent, for
2009; $97.7 billion, or 5.4 percent, for 2010; and $115.8 billion, or 6.0 percent, for 2011. For 2009,
downward revisions to profits of domestic financial corporations and to profits from the rest of the world
were partly offset by an upward revision to profits of domestic nonfinancial corporations. For 2010 and
2011, downward revisions to profits of domestic financial and nonfinancial corporations were partly
offset by an upward revision to profits from the rest of the world.

Profits before tax was revised down for all 3 years: $15.2 billion for 2009, $3.2 billion for 2010,
and $42.2 billion for 2011. The before-tax measure of profits does not reflect, as does profits from
current production, the capital consumption and inventory valuation adjustments. These adjustments
convert depreciation of fixed assets and inventory withdrawals reported on a tax-return, historical-cost
basis to the current-cost measures used in the national income and product accounts. The capital
consumption adjustment was revised down for all 3 years: $7.0 billion for 2009, $94.9 billion for 2010,
and $71.2 billion for 2011. The inventory valuation adjustment was revised up $2.6 billion for 2009,
was revised up $0.4 billion for 2010, and was revised down $2.5 billion for 2011.

Personal income was revised down for all 3 years: $63.2 billion, or 0.5 percent, for 2009; $51.6
billion, or 0.4 percent, for 2010; and $43.9 billion, or 0.3 percent, for 2011. For 2009, downward
revisions to personal dividend income, to rental income of persons, and to personal interest income were
partly offset by an upward revision to nonfarm proprietors? income. For 2010, a downward revision to
personal dividend income was partly offset by upward revisions to nonfarm proprietors? income and to
personal interest income. For 2011, downward revisions to personal dividend income, to government
social benefits to persons, and to farm proprietors? income were partly offset by upward revisions to
nonfarm proprietors? income, to supplements to wages and salaries, and to personal interest income.

Disposable personal income (DPI) (personal income less personal current taxes) was revised
down for all 3 years: $66.4 billion, or 0.6 percent, for 2009; $52.6 billion, or 0.5 percent, for 2010; and
$44.2 billion, or 0.4 percent, for 2011. Personal current taxes was revised up for all 3 years: $3.2 billion
for 2009, $0.9 billion for 2010, and $0.3 billion for 2011. The percent change from the preceding year
in real DPI was revised down from a decrease of 2.3 percent to a decrease of 2.8 percent for 2009, was
unrevised at 1.8 percent for 2010, and was revised up from an increase of 1.2 percent to an increase of
1.3 percent for 2011.

Personal outlays -- PCE, personal interest payments, and personal current transfer payments --
was revised down $22.0 billion for 2009, was revised down $26.5 billion for 2010, and was revised up
$4.8 billion for 2011. For 2009 and 2010, downward revisions to PCE accounted for most of the
revisions to personal outlays. For 2011, upward revisions to personal interest payments and to PCE
were partly offset by a downward revision to personal current transfer payments to government. The
personal saving rate (personal saving as a percentage of DPI) was revised down for all 3 years: from 5.1
percent to 4.7 percent for 2009, from 5.3 percent to 5.1 percent for 2010, and from 4.6 percent to 4.2
percent for 2011.

The statistical discrepancy is current-dollar GDP less current-dollar gross domestic income
(GDI). It arises because most components of GDP and of GDI are estimated independently. GDP
measures final expenditures -- the sum of consumer spending, private investment, net exports, and
government spending. GDI measures the incomes earned in the production of GDP. In concept, GDP is
equal to GDI. In practice, they differ because they are estimated using different source data and
different methods.

As a result of the annual revision, the statistical discrepancy as a percentage of GDP was revised
up for all 3 years: from 0.6 percent to 0.8 percent for 2009, from less than 0.1 percent to 0.2 percent for
2010, and from a negative 0.2 percent to a positive 0.2 percent for 2011. For 2009, the revision to the
discrepancy reflected an upward revision to GDP and a downward revision to GDI. For 2010 and 2011,
the revisions to the discrepancy reflected downward revisions to GDI that were larger than the
downward revisions to GDP.


New source data

The annual revision incorporated data from the following major federal statistical sources:
Census Bureau annual survey of manufactures for 2009 (revised) and 2010 (preliminary); Census
Bureau annual surveys of merchant wholesale trade and of retail trade for 2009 (revised) and for 2010
(preliminary); Census Bureau revised monthly indicators of manufactures, of merchant wholesale trade,
and of retail trade for 2009?2011; Census Bureau annual surveys of services for 2009 (revised), 2010
(revised), and 2011 (preliminary), and of state and local government finances for fiscal years 2008
(revised), 2009 (revised), and 2010 (preliminary); Census Bureau monthly survey of construction
spending (value put in place) for 2009?2011 (revised); Census Bureau quarterly services survey for
2009?2011 (revised); Census Bureau current population survey/housing vacancy survey for 2011;
federal government budget data for fiscal years 2011 and 2012; Internal Revenue Service tabulations of
tax returns for corporations for 2009 (revised) and 2010 (preliminary) and for sole proprietorships and
partnerships for 2010; Bureau of Labor Statistics quarterly census of employment and wages for 2009?
2011 (revised); Department of Agriculture farm statistics for 2009?2011 (revised); and BEA's ITAs for
2009?2011 (revised).


Changes in methodology and presentation

The annual revision also incorporated improvements to estimating methodologies, including the
following:

* Beginning with the estimates for 2010, data from the Census Bureau?s expanded service annual
survey (SAS) are incorporated into the annual estimates of PCE categories for ground
transportation for intercity buses, taxicabs, private urban transit systems, school bus
transportation, and "other" road transportation. Newly available SAS data are also incorporated
into the PCE estimates of water transportation; both ground transportation and water
transportation are included in the PCE category public transportation. In addition, newly
available SAS data are incorporated into the PCE estimates of commercial and vocational
schools and into the PCE estimates of water supply and sanitation services. Similarly, beginning
with the estimates for the first quarter of 2011, data from the Census Bureau?s expanded
quarterly services survey (QSS) are incorporated into the quarterly estimates of most of these
same PCE categories. As a result, the percentage of quarterly PCE services that are based on the
QSS has increased to 42 percent.

* Beginning with the estimates for 2010, retail motor vehicle inventory investment is derived using
a weighted average of private industry data on motor vehicle unit inventories and of inventory
data from the Census Bureau?s retail trade surveys. This methodology is used for both the
annual inventory investment estimates and the current quarterly extrapolations of inventory
investment. Prior to this methodology change, estimates of annual inventory investment were
based solely on retail trade inventory data from the Census Bureau, and the current quarterly
extrapolations were based solely on the unit inventory data. This new approach takes into
account differences in the scope and coverage of these two data sources and makes the annual
and current quarterly methodologies more consistent and should result in smaller revisions
during annual revisions.

* Beginning with the estimates for the second quarter of 2012, data for the "preliminary"
composite refiner acquisition cost of crude oil from the Energy Information Administration are
used in place of the producer price index for crude petroleum as the indicator for the estimates of
the refiner crude acquisition cost, which is used in the estimation of a number of important series
of private inventory investment and their corresponding inventory valuation adjustments.

* Beginning with the estimates for the first quarter of 2009, revised seasonally adjusted foreign
trade prices are incorporated on a "best-level" basis into BEA?s chained-dollar estimates of
exports and imports. The revised prices reflect BEA?s work with the Census Bureau?s Foreign
Trade Division to develop more consistent measures of chained-dollar exports and imports.

* A new group of tables is introduced on BEA?s Web site to show GDP, GDI, and other major
NIPA aggregates (including GNP and various command-basis measures) side-by-side. Most of
the measures in these tables are already available in other NIPA tables. The new tables are
intended to facilitate comparison of these major aggregates.

?

* * *


BEA's national, international, regional, and industry estimates; the Survey of Current Business;
and BEA news releases are available without charge on BEA's Web site at www.bea.gov. By visiting the
site, you can also subscribe to receive free e-mail summaries of BEA releases and announcements.


* * *


Next release -- August 29, 2012, at 8:30 A.M. EDT for:
Gross Domestic Product: Second Quarter 2012 (Second Estimate)
Corporate Profits: Second Quarter 2012 (Preliminary Estimate)

?


Comparisons of Revisions to GDP

Quarterly estimates of GDP are released on the following schedule: the "advance" estimate, based on
source data that are incomplete or subject to further revision by the source agency, is released near the end of the
first month after the end of the quarter; as more detailed and more comprehensive data become available,
the "second" and "third" estimates are released near the end of the second and third months, respectively.
The "latest"? estimate reflects the results of both annual and comprehensive revisions.

Annual revisions, which generally cover the quarters of the 3 most recent calendar years, are usually carried
out each summer and incorporate newly available major annual source data. Comprehensive (or benchmark)
revisions are carried out at about 5-year intervals and incorporate major periodic source data, as well as
improvements in concepts and methods that update the accounts to portray more accurately the evolving U.S.
economy.

The table below shows comparisons of the revisions between quarterly percent changes of current-dollar
and of real GDP for the different vintages of the estimates. From the advance estimate to the second estimate (one
month later), the average revision to real GDP without regard to sign is 0.5 percentage point, while from the
advance estimate to the third estimate (two months later), it is 0.6 percentage point. From the advance estimate to
the latest estimate, the average revision without regard to sign is 1.3 percentage points. The average revision
(with regard to sign) from the advance estimate to the latest estimate is 0.2 percentage point, which is larger
than the average revisions from the advance estimate to the second or to the third estimates. The larger average
revisions to the latest estimate reflect the fact that comprehensive revisions include major improvements, such as
the incorporation of BEA?s latest benchmark input-output accounts. The quarterly estimates correctly indicate the
direction of change of real GDP 97 percent of the time, correctly indicate whether GDP is accelerating or
decelerating 72 percent of the time, and correctly indicate whether real GDP growth is above, near, or below trend
growth more than four-fifths of the time.

Revisions Between Quarterly Percent Changes of GDP: Vintage Comparisons
[Annual rates]

Vintages Average Average without Standard deviation of
compared regard to sign revisions without
regard to sign

____________________________________________________Current-dollar GDP_______________________________________________

Advance to second.................... 0.2 0.6 0.4
Advance to third..................... .2 .7 .4
Second to third...................... .0 .3 .2

Advance to latest.................... .3 1.2 1.0

________________________________________________________Real GDP_____________________________________________________

Advance to second.................... 0.1 0.5 0.4
Advance to third..................... .1 .6 .5
Second to third...................... .0 .2 .2

Advance to latest.................... .2 1.3 1.0

NOTE. These comparisons are based on the period from 1983 through 2008.

-------------------------

ORIGINAL:

Here we go.

The major data point of the month is just minutes away: U.S. Second Quarter GDP.

Economists polled by Bloomberg forecast the economy expanded by 1.4 percent in the second quarter, below the 1.9 percent pace recorded in the first three months of the year.

Personal consumption is also expected to decelerate, increasing 1.3 percent.

This report may be muddied as the Bureau of Economic Analysis revises at least three years of data.?

Earlier this week,?Bank of America?Economist Michelle Meyer?told Bloomberg TV?that estimates from 2009 and 2010 "would likely still be lower, implying an even larger output gap, and, hence more slack in the economy."

The announcement is scheduled for 8:30 a.m.

Here's what to look for in the report >

Source: http://www.businessinsider.com/us-q2-gdp-2012-7

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Fake drugs leads to GSK recalls in SAfrica

JOHANNESBURG (Reuters) - GlaxoSmithKline said on Thursday it is recalling some of its over-the-counter headache medicine in South Africa after police discovered counterfeit versions of the painkiller.

A spokeswoman for GSK said the counterfeit versions of Grand-Pa Powders were limited to two batches, but declined to say how much was believed to be in circulation.

"We have no reason to suspect that other batches are affected," Liezl Sabbagh, marketing director for GSK's South African unit, adding the company was alerted to the drugs after police raided a drug counterfeiting operation.

State broadcaster SABC reported that police arrested a 45-year-old for allegedly manufacturing fake Grand-Pa powders in Oranjeville, a town in the Free State province about 100 km south of Johannesburg.

Grand-Pa is one of South Africa's top over-the-counter painkillers.

Source: http://news.yahoo.com/fake-drugs-leads-gsk-recalls-safrica-161059122--finance.html

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On world stage, Olympic culture clashes inevitable

LONDON (AP) ? In a way it was inevitable, given the size and scope of the event that is taking place in this most multicultural of capitals.

But the Olympic-sized political gaffes and cultural goofs already registered before the games officially open Friday have proven one thing in the globalized planet of the early 21st century: Even with the best of intentions, organizing an offense-free Olympics is nearly impossible.

On Thursday, three issues rankled some Muslim activists:

?A "Welcome to London" street sign written in Arabic that was virtually indecipherable, with the characters written backward.

?A ruling that one of Saudi Arabia's two female athletes couldn't wear a headscarf for her judo competitions because of safety concerns.

?And an insistence that two Moroccan soccer players produce a urine sample for doping tests, even though they were fasting for Ramadan and needed more than two hours to produce it.

"The reason we won the games was because London was diverse, it's where the world is represented," said Mohammed Shafiq, head of the Manchester-based Ramadan Foundation, which seeks to forge understanding among Britain's different communities.

"But," he said, "we're seeing decisions that are being made that will have a negative impact on the beliefs of Muslim athletes, and Muslim fans and officials."

Already, the International Olympic Committee and Prime Minister David Cameron have apologized profusely for the most blatant mistake to date: displaying South Korea's flag rather than North Korea's on a giant screen ahead of Pyongyang's inaugural women's soccer match Wednesday night. The flap sent the North's team off the pitch for an hour in protest.

On Thursday, two other geopolitical gaffes surfaced: Welsh soccer player Joe Allen was listed as English in the official program, and some athletes who were born in then-Soviet Ukraine were listed as having been born in the "Ukraine region" of Russia. Others were listed as coming from the Ukrainian cities of Lutsk and Lviv, which were described in the program as Russian. Similar mistakes were made for Georgia-born athletes.

Ukraine's Foreign Minister Konstantin Grishchenko said Kiev's embassy in London had complained to the IOC and requested corrections.

"The word 'region' is obviously excessive," he tweeted, referring to the centuries of Russian dominance that ended when Ukraine gained its independence in 1991. "It's an incompetent mistake even from the point of view of English grammar."

London organizing spokeswoman Joanne Manning-Cooper acknowledged the mistakes but tried to put them in context.

"We've got 200 competing nations from all over the world, a multitude of religions," she said. "Over the past seven years we've worked hard to make sure this really is everyone's games, no matter where you're from or what your beliefs."

Part of that involved creating a committee of representatives of different faiths to ensure no one would feel excluded by the games. But given the vast numbers of people and events involved ? 650 sporting events, nearly 10,000 athletes over 17 days ? mistakes are bound to happen.

"If we make mistakes, we fix them immediately and aim to ensure they never happen again," she said.

For Saudi Arabia's Wojdan Ali Seraj Abdulrahim Shahrkhani, it's not so much a mistake as a safety ruling that could jeopardize her participation in the games.

On Thursday, the International Judo Federation ruled she couldn't wear a headscarf during competition because of safety concerns given the strangleholds and chokeholds that are often used.

Shahrkhani is one of the first two Saudi women allowed to participate in the Olympics; the other, Sarah Attar is expected to wear a headscarf when she competes in distance running.

Asian judo federations have previously allowed Muslim women to wear the hijab during major competitions, but the IJF decided against it this time around.

"Someone wearing a headscarf could put their opponent at a disadvantage if the headscarf gets in the way and you're not able to grip properly," said Szandra Szogedi, a Hungarian fighter who just missed out on the Olympics and is helping the Hungarian team during the games.

Judo fighters typically struggle to get a grip on each other's uniform and frequently reach behind their opponent's head to get a dominant position on the base of their neck.

"But on the other hand, the headscarf could be dangerous for the woman wearing it, because if I try to strangle you and somehow pull your scarf around into a more dangerous position," she said.

Shafiq, of the Ramadan Foundation, said allowances should be made particularly for people of different faiths.

"It's not about political correctness," he said. "It's about being aware of the sensitivities around this, and positively embracing the diversity."

_____

Maria Cheng in London and Jim Heintz in Moscow contributed to this report.

Source: http://news.yahoo.com/world-stage-olympic-culture-clashes-inevitable-072214273--oly.html

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Wednesday, July 25, 2012

Donors give nearly $2 million to help Aurora shooting victims

[ [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

Source: http://news.yahoo.com/blogs/lookout/donors-nearly-2-million-help-aurora-shooting-victims-161904549.html

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Tuesday, July 24, 2012

Practical Garage Door Opener Tricks | Home Improvement Zones

Maybe you?re not a DIY expert, but learning these five easy tricks garage door opener can help you save time and make life a little easier on the road.

Today, many hardware professional and do-it-yourself experts television show focuses on the many easy ways to get your house in order and garage space. While many of them just give tips on furniture, very few really use some time for the exchange of quick tricks to ease the garage door opener.

For the first time homeowners, young people, pensioners and people are more likely than their peers from learning these simple tricks, you are good because they have less experience with newer models. Check out these tips and feel free to share some of your own.

Keep the remote start in a center console, or better yet, hide in the glove compartment ? the remote control is nothing but a key to the house. Leave it to display only potential thieves or troublemakers to promote.
Place the manual for the opener in a large zip-lock bag and tape to the inside of the door with duct tape ? to a certain point, you may need to reprogram or change the password for the device. Often chamber guide with valuable information about programming. It is still in a waterproof bag ensures that the moisture away from your site to store for later use.

Stop in the newspapers between the rail and the door to reduce noise ? Perhaps one of the most common problems for new, young and old owner is the sound of the door when lifted. Feeds newspaper between the door and took to prevent metal to metal vibration, whereby the noise.
Set the error to fall along the periphery and especially in the corners to prevent errors from homes near the sensor ? with her warm and dry indoors to the garage is the perfect habitat for the unfortunate animals such as spiders, ants, cockroaches and beetles. After some time, these parasites build up in the corners of the garage. Piles of dust, dirt and insects are not only evil ? they block the sensors and keep the door open properly. Place traps in the corners of the garage to keep free of disease, but they will be away from the sensitive electronics.

Apply a thin layer of water-repellent glass cleaner on the extent of the keyless entry pad ? is observed keyless entry systems designed with a weatherproof exterior. But this does not look like you keep it as new. A simple trick to water spots and streaks by covering the pad, a fine mist of water-repellent glass cleaner spray. Just be sure to do a little discreet area to test and clean before applying to entire surface.

This entry was posted in Garage. Bookmark the permalink.

Source: http://www.magellanmmgeo.com/1169/practical-garage-door-opener-tricks

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Mount Sinai researchers discover new target for vaccine development in abundant immune cells

Mount Sinai researchers discover new target for vaccine development in abundant immune cells [ Back to EurekAlert! ] Public release date: 24-Jul-2012
[ | E-mail | Share Share ]

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Certain white blood cells may be useful in vaccinating against blood-borne infections and HIV

White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Immunology, provides groundbreaking insight into possible new approaches in vaccine development for blood-borne infections and HIV.

Neutrophils are part of the so-called innate immune systemthe immune system encoded at birth that remains unchangedand are at the front lines defending against infection and inflammation. The research was led by Andrea Cerutti, MD, Professor of Medicine at Mount Sinai School of Medicine, and included an international team of investigators that also involved Irene Puga, PhD, of IMIM-Hospital del Mar in Barcelona, Spain, and Montserrat Cols, PhD, of Mount Sinai.

Researchers evaluated healthy human tissues key to the immune system to assess the abundance of neutrophils in the lymph nodes, tonsils, lymphoid tissue in the intestine, and the spleen. They found very few neutrophils in all areas but onethe region of the spleen called the marginal zone. The spleen is an organ whose primary role is as a filtration system for agents that cause infection and inflammation in the body. Looking more closely at these cells, they found that their role spanned beyond the innate immune system.

According to the study, neutrophils in the marginal zone express two molecules called BAFF and APRIL, which then activate immune cells called B-cells in the adaptive immune system, which is more sophisticated and dynamic than the innate immune system. Neutrophils signal BAFF and APRIL to reprogram B-cells to create different classes of antibodies, allowing the immune system to mount a more potent antibody response.

"Our study is important because we discovered a completely new function in an immune cell that has been studied since immunology research began," said Dr. Cerutti. "The interactivity of the neutrophils in the innate immune system with the B-cells of the more sophisticated adaptive immune system shows that neutrophils operate at a much higher level than previously thought and play a very critical role in mounting a robust response to infection."

Dr. Cerutti's team also evaluated the spleens of people with a condition called neutropenia, which is characterized by a shortage in neutrophils and a compromised immune system, and found that the marginal zones in the spleens of these patients had fewer B-cells and antibodies. This demonstrates the necessity of having neutrophils interact with marginal zone B-cells to generate an innate layer of antibody defense. The fact that the research team found an abundance of neutrophils and marginal zone B-cells in the spleens from healthy individuals, but not neutropenic patients, indicates that these cells are primed and prepared to launch multi-level antibody production in healthy humans, even in the absence of a pathogen.

"Since neutrophils boost and reprogram B-cells to strengthen the immune system regardless of whether there is an infection, we may be able to harness them in vaccine development to enhance immune protection," said Dr. Cerutti. "This has significant promise in vaccinating against blood-borne infections, as B-cells are the first line of defense to antigens in the circulatory system. If we can improve vaccines with neutrophil-activating agents, we may have a chance to boost B-cell antibody production, and improve immune protection."

With this new knowledge, Dr. Cerutti and his collaborator Meimei Shan, PhD, from Mount Sinai, are evaluating neutrophil activation and B-cell antibody production in rhesus monkeys vaccinated against Simian Immunodeficiency Virus (SIV), or HIV as it occurs in monkeys, using a vaccine that includes a chemical that activates neutrophils.

"Now that we know that neutrophils are important in the release of powerful antibody-inducing molecules, such as BAFF and APRIL, neutrophils become a potential target for protective vaccines against HIV and other infectious agents," said Dr. Cerutti. "The initial results of this SIV study are encouraging and demonstrate the enormous untapped potential of neutrophils in vaccine development."

Ongoing experiments are testing the generation of antibodies to SIV and the activation of neutrophils and B-cells in the blood, spleen, and intestinal and urogenital tracts, which are major sites of SIV/HIV entry. These measurements are conducted in animals vaccinated in the presence or absence of an agent that stimulates neutrophils. Ultimately, the ability of this vaccine to generate protection against SIV will be tested after challenging the vaccinated animals with a live virus.

###

This study was funded by the National Institutes of Health in Bethesda, Md.

About The Mount Sinai Medical Center

The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.

The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Of the top 20 hospitals in the United States, Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.

For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Mount Sinai researchers discover new target for vaccine development in abundant immune cells [ Back to EurekAlert! ] Public release date: 24-Jul-2012
[ | E-mail | Share Share ]

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine

Certain white blood cells may be useful in vaccinating against blood-borne infections and HIV

White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Immunology, provides groundbreaking insight into possible new approaches in vaccine development for blood-borne infections and HIV.

Neutrophils are part of the so-called innate immune systemthe immune system encoded at birth that remains unchangedand are at the front lines defending against infection and inflammation. The research was led by Andrea Cerutti, MD, Professor of Medicine at Mount Sinai School of Medicine, and included an international team of investigators that also involved Irene Puga, PhD, of IMIM-Hospital del Mar in Barcelona, Spain, and Montserrat Cols, PhD, of Mount Sinai.

Researchers evaluated healthy human tissues key to the immune system to assess the abundance of neutrophils in the lymph nodes, tonsils, lymphoid tissue in the intestine, and the spleen. They found very few neutrophils in all areas but onethe region of the spleen called the marginal zone. The spleen is an organ whose primary role is as a filtration system for agents that cause infection and inflammation in the body. Looking more closely at these cells, they found that their role spanned beyond the innate immune system.

According to the study, neutrophils in the marginal zone express two molecules called BAFF and APRIL, which then activate immune cells called B-cells in the adaptive immune system, which is more sophisticated and dynamic than the innate immune system. Neutrophils signal BAFF and APRIL to reprogram B-cells to create different classes of antibodies, allowing the immune system to mount a more potent antibody response.

"Our study is important because we discovered a completely new function in an immune cell that has been studied since immunology research began," said Dr. Cerutti. "The interactivity of the neutrophils in the innate immune system with the B-cells of the more sophisticated adaptive immune system shows that neutrophils operate at a much higher level than previously thought and play a very critical role in mounting a robust response to infection."

Dr. Cerutti's team also evaluated the spleens of people with a condition called neutropenia, which is characterized by a shortage in neutrophils and a compromised immune system, and found that the marginal zones in the spleens of these patients had fewer B-cells and antibodies. This demonstrates the necessity of having neutrophils interact with marginal zone B-cells to generate an innate layer of antibody defense. The fact that the research team found an abundance of neutrophils and marginal zone B-cells in the spleens from healthy individuals, but not neutropenic patients, indicates that these cells are primed and prepared to launch multi-level antibody production in healthy humans, even in the absence of a pathogen.

"Since neutrophils boost and reprogram B-cells to strengthen the immune system regardless of whether there is an infection, we may be able to harness them in vaccine development to enhance immune protection," said Dr. Cerutti. "This has significant promise in vaccinating against blood-borne infections, as B-cells are the first line of defense to antigens in the circulatory system. If we can improve vaccines with neutrophil-activating agents, we may have a chance to boost B-cell antibody production, and improve immune protection."

With this new knowledge, Dr. Cerutti and his collaborator Meimei Shan, PhD, from Mount Sinai, are evaluating neutrophil activation and B-cell antibody production in rhesus monkeys vaccinated against Simian Immunodeficiency Virus (SIV), or HIV as it occurs in monkeys, using a vaccine that includes a chemical that activates neutrophils.

"Now that we know that neutrophils are important in the release of powerful antibody-inducing molecules, such as BAFF and APRIL, neutrophils become a potential target for protective vaccines against HIV and other infectious agents," said Dr. Cerutti. "The initial results of this SIV study are encouraging and demonstrate the enormous untapped potential of neutrophils in vaccine development."

Ongoing experiments are testing the generation of antibodies to SIV and the activation of neutrophils and B-cells in the blood, spleen, and intestinal and urogenital tracts, which are major sites of SIV/HIV entry. These measurements are conducted in animals vaccinated in the presence or absence of an agent that stimulates neutrophils. Ultimately, the ability of this vaccine to generate protection against SIV will be tested after challenging the vaccinated animals with a live virus.

###

This study was funded by the National Institutes of Health in Bethesda, Md.

About The Mount Sinai Medical Center

The Mount Sinai Medical Center encompasses both The Mount Sinai Hospital and Mount Sinai School of Medicine. Established in 1968, Mount Sinai School of Medicine is one of the leading medical schools in the United States. The Medical School is noted for innovation in education, biomedical research, clinical care delivery, and local and global community service. It has more than 3,400 faculty in 32 departments and 14 research institutes, and ranks among the top 20 medical schools both in National Institutes of Health (NIH) funding and by U.S. News & World Report.

The Mount Sinai Hospital, founded in 1852, is a 1,171-bed tertiary- and quaternary-care teaching facility and one of the nation's oldest, largest and most-respected voluntary hospitals. In 2012, U.S. News & World Report ranked The Mount Sinai Hospital 14th on its elite Honor Roll of the nation's top hospitals based on reputation, safety, and other patient-care factors. Of the top 20 hospitals in the United States, Mount Sinai is one of 12 integrated academic medical centers whose medical school ranks among the top 20 in NIH funding and by U.S. News & World Report and whose hospital is on the U.S. News & World Report Honor Roll. Nearly 60,000 people were treated at Mount Sinai as inpatients last year, and approximately 560,000 outpatient visits took place.

For more information, visit http://www.mountsinai.org/.
Find Mount Sinai on:
Facebook: http://www.facebook.com/mountsinainyc
Twitter @mountsinainyc
YouTube: http://www.youtube.com/mountsinainy


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Source: http://www.eurekalert.org/pub_releases/2012-07/tmsh-msr072412.php

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Monday, July 23, 2012

Japan probes alleged cover-up at nuclear plant

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

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Source: http://news.yahoo.com/japan-probes-alleged-cover-nuclear-plant-072025036.html

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Online Internet Marketing Business | free world message

The way to write Convincing Brochures for a sale

When beginning your new business, one choice you should make involves the tone and individuality that you would like to infuse your business with is your advertising and sales campaign. Coming up with a range of pamphlets to publicize your services and products as well as sales promotions and events are a fundamental part of your marketing. Your marketing campaign will indicate to your consumers what exactly you are offering and the style in which you are offering it.

Advertising pamphlets, such as full color brochures, newsletters, or flyers can aid in the success of selling your product.

There are 3 necessary items to remember when writing newsletters. Foremost, you want the consumer to read the pamphlet. Next, you will want the customer to appreciate the message. Third, you want the customer to buy something after reading the sales brochure. first step in making powerful brochures is to design the advertisement flyers so that the potential customer will read through the brochures instead of giving them a quick glance ere throwing them in the trash. The wisest method to make certain that your full color brochures are looked over is to display on the cover of the pamphlet of exactly how your merchandise can help the customer. A catchy title and a few great graphics will help sell your products specifically if you have color brochures. Don't clutter the valuable cover with real estate, company logos, and company slogans. There's space for logos and slogans on the inside of the sales brochure.

When the consumer has read your brochure, it is to get them hooked by showing how your product is exactly what they need. If possible, make a tri fold brochure to complement your desired audience. To illustrate, if want to give out your full color brochures at a seminar, be sure to show how your product correlates with the seminar.

Once the customer looks through your flyer, now is the time to make the sale. A powerful system is to propose price decrease or a reduced rate on your merchandise if the consumer displays or mentions to thier friends and family your flyers. The the consumer feels that they are getting a special deal, and the consumer may even facilitate the initial sales contract.

Excellent, professional business stationery can impress customers and networking partners who may be wanting to do business with you. Utilizing creative slogans on your business stationery that are unique to your business helps other people in businesses to remember your business. Other eye-catching promotional items will create powerful impressions on consumers and networking partners.

Business stationery and marketing are a simple way to publicize your business enterprise. Brochures tell the general public know that your company exists, what products or services you are providing, and is a way of updating consumers to any differences that have happened in your company.

It is significant to remember to not only pass out the newsletters in print form, but think of ways to promote to the many people that are on the Internet daily. You can do this by placing your website address on all of your flyers. By doing this, promotional stationary and advertisements will boost your company's sales both offline and online.

Source: http://free-worldmessage.blogspot.com/2012/07/online-internet-marketing-business.html

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Pram and Proper! 10 Super Strollers to Suit Every Style

Bauer-Griffin When we spotted Natalie Portman and Benjamin Millepied strolling the streets of Paris with their son Aleph on June 18, we had to take note of their cool gear. The 1-year-old cutie hitched a ride in the 4moms Origami, a sleek power folding stroller with ultra modern features like headlights and an LCD screen. [...]

Source: http://feeds.celebritybabies.com/~r/celebrity-babies/~3/x5VZCWzFU90/

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